On this interview, Stephanie Seneff, Ph.D., a senior analysis scientist at MIT, opinions the well being impacts of glyphosate. She has simply completed writing a e book about glyphosate known as “Poisonous Legacy: How the Weedkiller Glyphosate is Destroying Our Well being and the Atmosphere,” which is anticipated to be printed in June 2021.
For years, glyphosate was assumed protected and claims of toxicity had been vehemently denied. However lately, research on glyphosate have been demonstrating toxicity even at very low ranges. Seneff additionally believes glyphosate publicity could also be a key participant in instances of extreme COVID-19, which we’ll unravel on this interview.
Glyphosate’s Mechanism of Motion
The “gly” in glyphosate really stands for the amino acid glycine. The glycine amino acid in glyphosate has a methylphosphonate group connected to its nitrogen atom, which is chargeable for its results and toxicity.
After finding out the analysis literature on glyphosate, Seneff has reached the conclusion that your physique generally substitutes glyphosate for the amino acid glycine when it’s setting up proteins, and this could have devastating penalties in some instances. The proteins created with glyphosate as a substitute of glycine merely don’t work as a result of glyphosate is way bigger than glycine and likewise negatively charged, and as a end result this alters essential bodily traits.
Monsanto’s personal analysis, courting again to the late Eighties, reveals that glyphosate accumulates in numerous tissues, even although they declare it doesn’t.1 The Monsanto researchers proposed that it was “integrated into” the proteins in the tissues. This isn’t broadly appreciated, even within the pure well being group.
Now, when you’ve got a distorted analog of glycine (within the type of glyphosate), the protein constructed from it just isn’t going to work prefer it’s speculated to. In her e book, Seneff particulars the amino acids in proteins which can be most prone to break due to what she calls a “glyphosate prone motif.”
“It’s actually fascinating biology and so terrifying whenever you suppose of the potential penalties, if I am proper,” she says. “It matches so properly with all of the ailments which can be going up dramatically in our society that I actually suppose I am onto one thing big right here.”
An fragrant amino acid known as EPSP synthase is a important enzyme that nearly absolutely will get disrupted by glyphosate by this mechanism of substituting for glycine. This will get a bit technical, however it will be significant. The plant model of EPSP synthase binds a phosphate group in its substrate phosphoenolpyruvate at a website the place there’s a highly-conserved glycine residue (extremely conserved often implies that it’s important for correct operate).
It has been proven experimentally that, in the event you change the DNA code in order that the glycine is substituted by an amino acid known as alanine (one additional methyl group), the enzyme turns into utterly insensitive to glyphosate at any focus. It additionally takes successful on phosphate binding due to the additional methyl group, however you possibly can tweak one other amino acid close by to repair this downside, whereas nonetheless preserving its insensitivity to glyphosate.
Researchers from Dow-Dupont did precisely this to a maize model of EPSP synthase utilizing CRISPR technology and had been in a position to create synthetically a model of the maize’s personal EPSP synthase that was utterly proof against glyphosate. The title of this paper is: “Desensitizing Plant EPSP Synthase to Glyphosate: Optimized World Sequence Context Accommodates a Glycine-to-Alanine Change within the Lively Website.”2
The shikimate pathway is the pathway that produces fragrant amino acids, that are important to people as we can’t create these amino acids in our physique. The argument is we’re not prone to glyphosate as a result of our cells do not have EPSP synthase — actually, they don’t have your entire shikimate pathway.
Nevertheless, our intestine microbes do have that pathway, they usually use it to make important amino acids for the host. So, our gut microbes are certainly affected by glyphosate, and once they’re broken, our well being can endure in any variety of methods.
However what is perhaps an much more devastating downside with glyphosate is the way in which it most likely messes up a big variety of proteins that bind phosphate at a website the place there may be no less than one, and infrequently three, extremely conserved glycine residues. Glyphosate slips its methylphosphonate group into the spot that’s speculated to be the place phosphate from the substrate suits snugly. Phosphate can’t bind as a result of glyphosate is in the way in which.
The arguments for why glyphosate particularly disrupts proteins that rely upon glycine for phosphate binding are described extra absolutely in a paper Seneff printed along with colleagues arguing that glyphosate is a significant factor in kidney failure amongst younger agricultural employees in Central America.3
The Significance of Deuterium
Laszlo Boros is a professor of pediatrics at UCLA and an knowledgeable on deutenomics, “the science of autonomic deuterium discrimination in nature.”4 After studying one in all Seneff’s papers, he contacted her, suggesting she look into deuterium.
“I used to be blown away, and I instantly noticed the connection to glyphosate,” she says. “This was a yr in the past in December, and I’ve simply been studying every little thing I can on deuterium since then and hooking it to glyphosate. It is simply astonishing what I discovered, even, in the end, [linking it] to COVID-19.
It has been fairly a yr for me by way of main breakthroughs in my understanding of how metabolism works and the way it’s getting tousled by glyphosate, after which how that is inflicting us to not have the option to successfully take care of COVID-19.”
In regular physiology, your cells, particularly the mitochondria, operate to assist deplete your physique of deuterium. Deuterium is a naturally occurring isotope of hydrogen. Should you didn’t already know, deuterium is also referred to as heavy hydrogen, as a result of it has a neutron in addition to the proton and electron within the hydrogen atom.
Offered your cell is wholesome, it has deuterium-depleting enzymes and organelles that assist take away deuterium out of your cells. In case your mitochondria are broken by glyphosate, they’re not going to have the ability to remove the deuterium correctly.
Deuterium is like iron in the way in which that it’s each important in the appropriate quantities and poisonous in extra. Hydrogen is the smallest atom and by far the most typical atom in your physique. Deuterium, being a heavy hydrogen, has one additional neutron, along with the traditional proton and electron that common hydrogen has.
Now, your cells are surrounded by structured water, which is negatively charged and contributes to your physique’s power manufacturing by supplying deuterium-depleted hydrogen to lysosomes and mitochondria. The structured water is maintained by sulfates, which makes sulfate extraordinarily essential for well being. Sulfate is made dysfunctional by glyphosate, which in flip destroys structured water, leading to impaired power manufacturing within the cell.5
“The mitochondria have [a] membrane, which has an element contained in the membrane that is actually, actually essential,” Seneff says. “That is the place you’ve these protons, and you actually don’t desire it to be deuterons. That is what Laszlo introduced dwelling to me.”
How Your Physique Creates Deuterium-Depleted Water
Endothelial NOS (eNOS) makes nitric oxide (NO), and for each molecule of NO that it makes, it produces two molecules of water, that are deuterium depleted. Stephanie believes the NO created by eNOS might act as a sign that deuterium-depleted water has been created. Apparently sufficient, deuterium-depleted water can also be created throughout the inflammatory course of.
“The irritation is there for a very good purpose, and the reason being to produce deuterium-depleted water,” Seneff says. “It’s all as a result of the mitochondria are failing of their job of producing their very own deuterium-depleted water, which they get partially by the structured water from the sulfate [and] by enzymes which can be extremely expert at selecting hydrogen over deuterium …
NADH and NADPH are additionally fascinating. I have been chasing them by all of the proteins. They’re attention-grabbing as a result of they’re the carriers of that great hydrogen that is not deuterium. Once you hint what’s doing what, the place, you understand that the cytoplasm is producing NADH and handing it over to the mitochondria.
The mitochondria then take that H [hydrogen atom] off and throw it into the intermembrane house. So, the entire course of finally ends up with the intermembrane house being assured that that is H [hydrogen] and never D [deuterium].
That is essential as a result of then these protons, as soon as they construct up, come again by the ATPase [ATP synthase] pump. If they’re deuterons, they’ll wreck the pump … You launch reactive oxygen species [that] break it, and naturally, then you possibly can’t make ATP.”
For clarification, the ATP synthase pump works like a mini-motor. When a hydrogen atom with one proton goes by it, it really works flawlessly and generates ATP. If deuterium enters it, which has one neutron and one proton, making it twice the burden of hydrogen, it breaks that motor.
Apparently, deuterium is all over the place, naturally, however your physique has developed an intricate technique to make it innocent by trapping it within the structured water, the place it’s useful, because it really helps the creation of structured water.
Issues come up whenever you can’t make sufficient structured water to sequester all of it. Then, the deuterium will get free, inflicting mitochondrial dysfunction, impairing power manufacturing and contributing to continual illness.
Glyphosate Damages Well being in Many Methods
As famous by Seneff, glyphosate harms your well being in a lot of methods. For instance, she cites a current paper exhibiting it causes endocrine disruption, which can result in breast most cancers, reproductive points, weight problems and thyroid issues.6
One other paper reveals glyphosate sensitizes cells to be extra receptive to most cancers after publicity to different chemical compounds.7 “Glyphosate makes every little thing else extra poisonous than it might in any other case be,” Seneff says. “It disrupts your protection system towards poisonous chemical compounds.” Different analysis reveals epigenetic and generational results, even when no obvious issues will be discovered within the first era uncovered.8
Glyphosate additionally impairs flavoproteins — proteins that bind flavins. Many of those proteins play an important position in transferring hydrogen from NADH or NADPH to different molecules, primarily supporting the supply of pure hydrogen to the mitochondria. Flavoproteins have a attribute GxGxxG motif on the website the place they bind phosphate within the flavins. The ‘G’ stands for glycine and the ‘x’ is a wildcard — any amino acid, together with glycine.
This implies they have no less than three prone glycines at this important area of the protein. Flavoproteins are molecules that facilitate the switch of protons and electrons, and know the best way to keep away from deuterium, by exploiting a particular function of hydrogen known as proton tunneling.
All of them can be anticipated to be disrupted by glyphosate. A important flavoprotein is succinate dehydrogenase, and a number of other papers have proven it’s adversely affected by glyphosate, Seneff says. It’s the solely enzyme that performs a task in each oxidative phosphorylation and the citric acid cycle within the mitochondria.
Along with fragrant amino acids, the shikimate pathway is important for riboflavin synthesis, and riboflavin, a B vitamin, is the principle precursor to flavins. Which means riboflavin deficiency will be triggered from glyphosate publicity as properly.
Glyphosate additionally causes harm by:
- Rising calcium uptake in cells, which causes toxicity to neurons
- Interfering with the power to take glutamate out of your synapses
- Making manganese unavailable — This in flip disrupts and prevents glutamate from being changed into unhazardous glutamine after it’s eliminated out of your synapses. The enzyme chargeable for the conversion can also be extremely depending on glycine, which might be changed by glyphosate
Deuterium-Depleted Water Could Be Central to Metabolism
In response to Seneff, it seems deuterium-depleted water performs a central, hitherto unappreciated position in metabolism, as your physique has so some ways to create it. For instance, deuterium-depleted water is created by:
• Fatty acid synthesis and metabolism — The enzymes that synthesize fatty acids incorporate hydrogen that is carried by NADPH. This hydrogen atom has been rigorously chosen to be assured to not be deuterium. Apparently, lipoxygenase is a protein expressed throughout situations of stress, and in line with Seneff, it has the best capability to pick protons over deuterons of any protein.
It’s extremely upregulated in extreme COVID-19 an infection. It seems the virus triggers a rise in lipoxygenase as a result of the virus captures linoleic acid (LA) in pockets within the viral membrane. Nevertheless, lipoxygenase is not a flavoprotein, and it additionally doesn’t bind heme — this makes it proof against harm from glyphosate. So, its activation turns into an alternate pathway to repair the mitochondrial deuterium downside.
SARS-CoV-2 picks up the omega-6 LA because it crosses the mobile membrane, and the LA then triggers the manufacturing of lipoxygenase that modifies the LA into leukotrienes — signaling molecules that herald damaging macrophages.
However deuterium-depleted water can also be produced on this course of, by yanking two hydrogen atoms out of the fats and mixing them with oxygen to make water. Be aware that that is simply yet one more manner that extra LA damages your physique, however with an ulterior motive that we regularly fail to understand.
• Sterol synthesis and metabolism — together with ldl cholesterol, vitamin D, cortisol, and intercourse hormones.
• Fragrant amino acid derivatives — together with melatonin and neurotransmitters comparable to dopamine and serotonin, in addition to thyroid hormone.
“All these molecules that undergo these difficult steps are all centered on delivering deuterium-depleted water to the mitochondria,” Seneff says. “I imply, it is an absolute obsession that the cell has.” She goes on to assessment how processes that might seem to don’t have anything however dangerous results are literally an effort to heal the physique. This, for instance, appears to be the case in COVID-19:
“I consider that no matter biology is doing, it is doing it for a very good purpose. There could also be harm, however there is a good purpose why you want that harm so as to survive long run. It is making an attempt to repair an issue that is very severe, and that is what I believe is occurring with [SARS-CoV-2].
Not solely does it induce this lipoxygenase, which produces deuterium-depleted water, it then creates this inflammatory atmosphere, which brings within the platelets and the macrophages, the immune cells and the stem cells. All these are having a giant occasion in there in all this fluid that is increase contained in the lungs.
In the meantime, it additionally will increase the manufacturing of hyaluronic acid. Hyaluronic acid is ready to entice deuterium-depleted water. It makes structured water. So, you get structured water contained in the alveoli of the lungs, after which you get fluid water within the interstitial areas.
The blood vessels are leaky, the capillaries are leaky. All the pieces’s popping out of the capillaries into this interstitial house the place there’s this fluid water, and you have this lipoxygenase making deuterium-depleted water.
So, you are producing this atmosphere of deuterium-depleted water, inviting the macrophages to come back in, and the platelets launch their mitochondria … the stem cells additionally are available in and launch their mitochondria, and then macrophages sweep up the mitochondria — and all that is occurring within the interstitial house within the lungs the place the fluid is. For this reason you can’t breathe. You are drowning.
Perhaps some of the essential issues platelets do is hold on to mitochondria that they will ship to the macrophages beneath situations of stress. So, what occurs is all these mitochondria get launched in that interstitial house, and the macrophages induce this macropinocytosis, the place they really sweep up the water and every little thing that is in it and convey it contained in the macrophage, together with the mitochondria.
It is really been proven that platelets can launch mitochondria into the atmosphere, and macrophages can take them up and use them as completely functioning mitochondria. It is astonishing. So, what they’re doing is restoring the mitochondrial well being to the immune cells.”
Glyphosate Injury Could Be a Consider Extreme COVID-19
As defined by Seneff, your immune cells are impaired by glyphosate, so the older you’re, the extra seemingly you’ve been uncovered to glyphosate for many years and due to this fact have poorly functioning immune cells. Apparently, Seneff factors out that the comorbidities of COVID-19 — weight problems, diabetes and hypertension — are additionally ailments whose prevalence goes up dramatically over time, precisely in step with glyphosate utilization on core crops.
“So, I believe it is principally about glyphosate,” she says. “Should you’ve amassed a variety of glyphosate in your tissues, you are not going to do properly with COVID-19, and that is as a result of [your body] is making an attempt to restore the mitochondria within the immune cells in order that the immune cells can really clear the virus. If they can not make ATP, they can not do their job, and the virus thrives.”
The important thing take-home message right here is that that is but one more reason to scrub up your food plan to be sure to’re not uncovered to glyphosate. It mainly wrecks your immune cells, and the cascading harm that takes place in extreme instances of COVID-19 seems to be your physique’s response to salvage or restore these poorly functioning immune cells.
The reply to this downside is, initially, to eat licensed natural meals every time doable. “We cannot purchase it if we won’t discover licensed natural, and we have actually seen well being enhancements since we have began doing that,” Seneff says. “I actually swear by it, and I attempt to get all my buddies to do the identical. I believe if you possibly can remove glyphosate, you possibly can actually see nice enhancements in your well being it doesn’t matter what your issues are.” Different dietary suggestions embody consuming/ingesting extra:
Sulfur-containing meals comparable to natural eggs and seafood
Natural grass fed milk and butter. Butter is likely one of the lowest deuterium meals obtainable
Glacier water, which is of course low in deuterium
Animal fat, that are additionally low in deuterium
Probiotics meals comparable to sauerkraut and apple cider vinegar
To assist “push” glyphosate out of your physique and mitigate its toxicity, you possibly can take an affordable glycine complement. I take between 5 and 10 grams a day. It has a light-weight, candy style, so you possibly can really use it as a sweetener.
“It is smart as a result of it is mainly going to outnumber the glyphosate molecules,” Seneff says. “Keep in mind, glyphosate’s going to compete with glycine in constructing the protein. If there’s a variety of glycine round, then it is a lot much less seemingly that glyphosate will get in there.”